N-[4-[[(2,4-DiaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid-d3 DiMethyl Ester - Names and Identifiers
N-[4-[[(2,4-DiaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid-d3 DiMethyl Ester - Physico-chemical Properties
Molecular Formula | C22H26N8O5
|
Molar Mass | 482.49244 |
Melting Point | >109°C (dec.) |
Solubility | DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated) |
Appearance | Solid |
Color | Yellow to Very Dark Yellow |
Storage Condition | Hygroscopic, Refrigerator, Under Inert Atmosphere |
Stability | Hygroscopic |
N-[4-[[(2,4-DiaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid-d3 DiMethyl Ester - Introduction
Methotrexate-d3 Ester (methyl amidoester-d3 Dimethyl Ester) is a labeled compound that is a deuterated propynyl aminoethyl Ester derivative of Methotrexate (methyl amidoester). It has similar properties, but three of its hydrogen atoms are replaced by deuterium.
The main use of Methotrexate-d3 dimer Ester is as an internal standard or labeled compound in drug metabolism and bioanalytical research. It can be used to study the pharmacokinetics of Methotrexate, drug interactions, and pathways of biotransformation.
The method of preparing Methotrexate-d3 Dimethyl Ester usually involves deuteration of Methotrexate. A common preparation method is to react Methotrexate with sodium deuteride (NaOD) in methyl formate to give the deuterated compound.
safety information, since Methotrexate-d3 dimer Ester is a chemical marker, the use must comply with laboratory safety procedures. It may be irritating to the skin, eyes and respiratory system, so wear appropriate personal protective equipment when handling. In addition, it should be stored in a dry, cool and dark place, away from fire and oxidizing agents.
Please note that Methotrexate-d3 dimer Ester is a research compound, the specific use and preparation method may require further laboratory operation and understanding. In practical applications, it is important to follow appropriate safety procedures and relevant regulations.
Last Update:2024-04-09 21:04:16